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1 | # Deep GONet | 1 | # Deep GONet |
2 | 2 | ||
3 | -From the article entitled **Deep GONet: Self-explainable deep neural network based on Gene Ontology for phenotype prediction from gene expression data** (submitted to APBC 2021) by Victoria Bourgeais, Farida Zehraoui, Mohamed Ben Hamdoune, and Blaise Hanczar. | 3 | +Original code from the article entitled **Deep GONet: Self-explainable deep neural network based on Gene Ontology for phenotype prediction from gene expression data** (accepted both in APBC 2021 and BMC Bioinformatics) by Victoria Bourgeais, Farida Zehraoui, Mohamed Ben Hamdoune, and Blaise Hanczar. |
4 | 4 | ||
5 | --- | 5 | --- |
6 | 6 | ||
... | @@ -14,7 +14,7 @@ The code is implemented in Python using the [Tensorflow](https://www.tensorflow. | ... | @@ -14,7 +14,7 @@ The code is implemented in Python using the [Tensorflow](https://www.tensorflow. |
14 | 14 | ||
15 | ### Dataset | 15 | ### Dataset |
16 | 16 | ||
17 | -The full dataset can be downloaded on ArrayExpress database under the id [E-MTAB-3732](https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-3732/). Here, you can find the pre-processed training and test sets: | 17 | +The full microarray dataset can be downloaded on ArrayExpress database under the id [E-MTAB-3732](https://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-3732/). Here, you can find the pre-processed training and test sets: |
18 | 18 | ||
19 | [training set](https://entrepot.ibisc.univ-evry.fr/f/5b57ab5a69de4f6ab26b/?dl=1) | 19 | [training set](https://entrepot.ibisc.univ-evry.fr/f/5b57ab5a69de4f6ab26b/?dl=1) |
20 | 20 | ||
... | @@ -22,9 +22,12 @@ The full dataset can be downloaded on ArrayExpress database under the id [E-MTAB | ... | @@ -22,9 +22,12 @@ The full dataset can be downloaded on ArrayExpress database under the id [E-MTAB |
22 | 22 | ||
23 | Additional files for NN architecture: [filesforNNarch](https://entrepot.ibisc.univ-evry.fr/f/6f1c513798df41999b5d/?dl=1) | 23 | Additional files for NN architecture: [filesforNNarch](https://entrepot.ibisc.univ-evry.fr/f/6f1c513798df41999b5d/?dl=1) |
24 | 24 | ||
25 | +TCGA dataset can be downloaded from [GDC portal](https://portal.gdc.cancer.gov/). | ||
26 | + | ||
25 | ### Usage | 27 | ### Usage |
26 | 28 | ||
27 | -Deep GONet was achieved with the $L_{GO}$ regularization and the hyperparameter $\alpha=1e^{-2}$. | 29 | +The following show how to train and evaluate the neural network. |
30 | +Deep GONet was achieved with the $L_{GO}$ regularization and the hyperparameter $\alpha=1e^{-2}$ on the microarray dataset. | ||
28 | To replicate it, the command line flag *type_training* needs to be set to LGO (default value) and the command line flag *alpha* to $1e^{-2}$ (default value). | 31 | To replicate it, the command line flag *type_training* needs to be set to LGO (default value) and the command line flag *alpha* to $1e^{-2}$ (default value). |
29 | 32 | ||
30 | There exists 3 functions (flag *processing*): one is dedicated to the training of the model (*train*), another one to the evaluation of the model on the test set (*evaluate*), and the last one to the prediction of the outcomes of the samples from the test set (*predict*). | 33 | There exists 3 functions (flag *processing*): one is dedicated to the training of the model (*train*), another one to the evaluation of the model on the test set (*evaluate*), and the last one to the prediction of the outcomes of the samples from the test set (*predict*). |
... | @@ -86,4 +89,9 @@ python DeepGONet.py --alpha=0 --EPOCHS=100 --is_training=True --display_step=5 - | ... | @@ -86,4 +89,9 @@ python DeepGONet.py --alpha=0 --EPOCHS=100 --is_training=True --display_step=5 - |
86 | 89 | ||
87 | ### Interpretation tool | 90 | ### Interpretation tool |
88 | 91 | ||
89 | -Please see the notebook entitled *Interpretation_tool.ipynb* to perform the biological interpretation of the results. | ||
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92 | +Please see the notebook entitled *Interpretation_tool.ipynb* to perform the biological interpretation of the results. | ||
93 | + | ||
94 | +## How to cite this work? | ||
95 | + | ||
96 | +Bourgeais, V., Zehraoui, F., Ben Hamdoune, M., & Hanczar, B. (2021). Deep GONet: Self-explainable deep neural network based on Gene Ontology for phenotype prediction from gene expression data. BMC Bioinformatics, 22(10), 455. https://doi.org/10.1186/s12859-021-04370-7 | ||
97 | + | ... | ... |
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